6B5T

Structure of PfCSP peptide 29 with human antibody CIS42

Summary for 6B5T

Entry DOI	10.2210/pdb6b5t/pdb
Related	6B5P 6B5R 6B5S
Descriptor	pfCSP peptide 29: ALA-ASN-PRO-ASN-ALA-ASN-PRO-ASN-ALA-ASN-PRO-ASN-ALA, CIS42 Fab Heavy chain, CIS42 Fab Light chain, ... (5 entities in total)
Functional Keywords	malaria, pfcsp, vaccine, antibodies, immune system
Biological source	Homo sapiens More
Total number of polymer chains	3
Total formula weight	47897.17
Authors	Pancera, M.,Weidle, C. (deposition date: 2017-09-29, release date: 2018-03-21, Last modification date: 2018-04-25)
Primary citation	Kisalu, N.K.,Idris, A.H.,Weidle, C.,Flores-Garcia, Y.,Flynn, B.J.,Sack, B.K.,Murphy, S.,Schon, A.,Freire, E.,Francica, J.R.,Miller, A.B.,Gregory, J.,March, S.,Liao, H.X.,Haynes, B.F.,Wiehe, K.,Trama, A.M.,Saunders, K.O.,Gladden, M.A.,Monroe, A.,Bonsignori, M.,Kanekiyo, M.,Wheatley, A.K.,McDermott, A.B.,Farney, S.K.,Chuang, G.Y.,Zhang, B.,Kc, N.,Chakravarty, S.,Kwong, P.D.,Sinnis, P.,Bhatia, S.N.,Kappe, S.H.I.,Sim, B.K.L.,Hoffman, S.L.,Zavala, F.,Pancera, M.,Seder, R.A. A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite. Nat. Med., 24:408-416, 2018 Cited by PubMed: 29554083 DOI: 10.1038/nm.4512 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.222 Å)

Structure validation