6B3Q

Cryo-EM structure of human insulin degrading enzyme in complex with insulin

Summary for 6B3Q

Entry DOI	10.2210/pdb6b3q/pdb
Related	6B70 6B7Y 6B7Z
EMDB information	7041 7062 7065 7066
Descriptor	Insulin-degrading enzyme, Insulin (2 entities in total)
Functional Keywords	ide, insulin degrading enzyme, amyloid beta, hydrolase-hormone complex, hydrolase/hormone
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	253102.85
Authors	Liang, W.G.,Zhang, Z.,Bailey, L.J.,Kossiakoff, A.A.,Tan, Y.Z.,Wei, H.,Carragher, B.,Potter, S.C.,Tang, W.J. (deposition date: 2017-09-22, release date: 2017-11-22, Last modification date: 2021-04-28)
Primary citation	Zhang, Z.,Liang, W.G.,Bailey, L.J.,Tan, Y.Z.,Wei, H.,Wang, A.,Farcasanu, M.,Woods, V.A.,McCord, L.A.,Lee, D.,Shang, W.,Deprez-Poulain, R.,Deprez, B.,Liu, D.R.,Koide, A.,Koide, S.,Kossiakoff, A.A.,Li, S.,Carragher, B.,Potter, C.S.,Tang, W.J. Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7:-, 2018 Cited by PubMed: 29596046 DOI: 10.7554/eLife.33572 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.7 Å)

Structure validation