6AK4

Crystal structure of human FTO in complex with small-molecule inhibitors

Summary for 6AK4

• Entry DOI: 10.2210/pdb6ak4/pdb
• Related: 6AEJ
• Descriptor: Alpha-ketoglutarate-dependent dioxygenase FTO,Alpha-ketoglutarate-dependent dioxygenase FTO, ZINC ION, (~{E})-2-cyano-~{N},~{N}-diethyl-3-[3-nitro-4,5-bis(oxidanyl)phenyl]prop-2-enamide (3 entities in total)
• Functional Keywords: oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 1
• Total formula weight: 54492.67

Authors

Wang, Y.,Cao, R.,Peng, S.,Zhang, W.,Huang, N. (deposition date: 2018-08-30, release date: 2019-07-10, Last modification date: 2023-11-22)

• Primary citation: Peng, S.,Xiao, W.,Ju, D.,Sun, B.,Hou, N.,Liu, Q.,Wang, Y.,Zhao, H.,Gao, C.,Zhang, S.,Cao, R.,Li, P.,Huang, H.,Ma, Y.,Wang, Y.,Lai, W.,Ma, Z.,Zhang, W.,Huang, S.,Wang, H.,Zhang, Z.,Zhao, L.,Cai, T.,Zhao, Y.L.,Wang, F.,Nie, Y.,Zhi, G.,Yang, Y.G.,Zhang, E.E.,Huang, N.; Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1.; Sci Transl Med, 11:-, 2019; PubMed: 30996080; DOI: 10.1126/scitranslmed.aau7116

Experimental method

X-RAY DIFFRACTION (2.8 Å)