6AJY
Crystal structure of BRD4 in complex with 2',4'-dihydroxy-2-methoxychalcone
Summary for 6AJY
| Entry DOI | 10.2210/pdb6ajy/pdb |
| Descriptor | Bromodomain-containing protein 4, 2',4'-dihydroxy-2-methoxychalcone, SODIUM ION, ... (4 entities in total) |
| Functional Keywords | bromodomain, brd4, inhibitor, isoliquiritigenin, transcription |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 16476.82 |
| Authors | Yokoyama, T.,Matsumoto, K.,Nabeshima, Y.,Mizuguchi, M. (deposition date: 2018-08-28, release date: 2019-06-12, Last modification date: 2024-03-27) |
| Primary citation | Yokoyama, T.,Matsumoto, K.,Ostermann, A.,Schrader, T.E.,Nabeshima, Y.,Mizuguchi, M. Structural and thermodynamic characterization of the binding of isoliquiritigenin to the first bromodomain of BRD4. Febs J., 286:1656-1667, 2019 Cited by PubMed: 30565859DOI: 10.1111/febs.14736 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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