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6AFE

DJ-1 with compound 7

Summary for 6AFE
Entry DOI10.2210/pdb6afe/pdb
DescriptorProtein/nucleic acid deglycase DJ-1, 7-(trifluoromethyl)-1~{H}-indole-2,3-dione, CHLORIDE ION, ... (4 entities in total)
Functional Keywordsdj-1, parkinson's disease, drug discovery, fragment-based drug discovery, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight20382.76
Authors
Caaveiro, J.M.M.,Tashiro, S.,Tsumoto, K. (deposition date: 2018-08-08, release date: 2018-08-29, Last modification date: 2023-11-22)
Primary citationTashiro, S.,Caaveiro, J.M.M.,Nakakido, M.,Tanabe, A.,Nagatoishi, S.,Tamura, Y.,Matsuda, N.,Liu, D.,Hoang, Q.Q.,Tsumoto, K.
Discovery and Optimization of Inhibitors of the Parkinson's Disease Associated Protein DJ-1.
ACS Chem. Biol., 13:2783-2793, 2018
Cited by
PubMed: 30063823
DOI: 10.1021/acschembio.8b00701
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.5 Å)
Structure validation

217705

數據於2024-03-27公開中

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