6A9O

Rational discovery of a SOD1 tryptophan oxidation inhibitor with therapeutic potential for amyotrophic lateral sclerosis

Summary for 6A9O

• Entry DOI: 10.2210/pdb6a9o/pdb
• Descriptor: Superoxide dismutase [Cu-Zn], ZINC ION, DIMETHYL SULFOXIDE, ... (7 entities in total)
• Functional Keywords: dismutase, dimer, oxidation, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 10
• Total formula weight: 161526.16

Authors

Manjula, R.,Padmanabhan, B. (deposition date: 2018-07-14, release date: 2019-07-17, Last modification date: 2023-11-22)

• Primary citation: Manjula, R.,Unni, S.,Wright, G.S.A.,Bharath M M, S.,Padmanabhan, B.; Rational discovery of a SOD1 tryptophan oxidation inhibitor with therapeutic potential for amyotrophic lateral sclerosis.; J.Biomol.Struct.Dyn., 37:3936-3946, 2019; PubMed: 30286701; DOI: 10.1080/07391102.2018.1531787

Experimental method

X-RAY DIFFRACTION (2.5 Å)