6A5F

The structure of [4+2] and [6+4] cyclase in the biosynthetic pathway of nargenicin

Summary for 6A5F

• Entry DOI: 10.2210/pdb6a5f/pdb
• Descriptor: NgnD (2 entities in total)
• Functional Keywords: nargenicin, biosynthesis, biosynthetic protein
• Biological source: Nocardia argentinensis ATCC 31306
• Total number of polymer chains: 2
• Total formula weight: 36187.98

Authors

Zhang, B.,Ge, H.M. (deposition date: 2018-06-23, release date: 2019-02-06, Last modification date: 2024-03-27)

• Primary citation: Zhang, B.,Wang, K.B.,Wang, W.,Wang, X.,Liu, F.,Zhu, J.,Shi, J.,Li, L.Y.,Han, H.,Xu, K.,Qiao, H.Y.,Zhang, X.,Jiao, R.H.,Houk, K.N.,Liang, Y.,Tan, R.X.,Ge, H.M.; Enzyme-catalysed [6+4] cycloadditions in the biosynthesis of natural products.; Nature, 568:122-126, 2019; PubMed: 30867595; DOI: 10.1038/s41586-019-1021-x

Experimental method

X-RAY DIFFRACTION (2.05 Å)