The structure of [4+2] and [6+4] cyclase in the biosynthetic pathway of nargenicin

Summary for 6A5F

DescriptorNgnD (2 entities in total)
Functional Keywordsnargenicin, biosynthesis, biosynthetic protein
Biological sourceNocardia argentinensis ATCC 31306
Total number of polymer chains2
Total molecular weight36187.98
Zhang, B.,Ge, H.M. (deposition date: 2018-06-23, release date: 2019-02-06, Last modification date: 2019-04-17)
Primary citation
Zhang, B.,Wang, K.B.,Wang, W.,Wang, X.,Liu, F.,Zhu, J.,Shi, J.,Li, L.Y.,Han, H.,Xu, K.,Qiao, H.Y.,Zhang, X.,Jiao, R.H.,Houk, K.N.,Liang, Y.,Tan, R.X.,Ge, H.M.
Enzyme-catalysed [6+4] cycloadditions in the biosynthesis of natural products.
Nature, 568:122-126, 2019
PubMed: 30867595 (PDB entries with the same primary citation)
DOI: 10.1038/s41586-019-1021-x
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.1842 0.3% 3.4% 1.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report