6Z79
Variant Surface Glycoprotein VSGsur, I3C ("Magic Triangle") derivative used for phasing of the structure and subsequently as a model for molecular replacement of native, mutants, and drug soaks.
Summary for 6Z79
Entry DOI | 10.2210/pdb6z79/pdb |
Descriptor | Variant surface glycoprotein Sur, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid, ... (4 entities in total) |
Functional Keywords | variant surface glycoprotein suramin trypanosomiasis drug resistance glycosylation magic triangle i3c, membrane protein |
Biological source | Trypanosoma brucei rhodesiense |
Total number of polymer chains | 1 |
Total formula weight | 53937.74 |
Authors | Zeelen, J.P.,Straaten van, M.,Stebbins, C.E. (deposition date: 2020-05-30, release date: 2021-03-17) |
Primary citation | Zeelen, J.,van Straaten, M.,Verdi, J.,Hempelmann, A.,Hashemi, H.,Perez, K.,Jeffrey, P.D.,Halg, S.,Wiedemar, N.,Maser, P.,Papavasiliou, F.N.,Stebbins, C.E. Structure of trypanosome coat protein VSGsur and function in suramin resistance. Nat Microbiol, 6:392-400, 2021 Cited by PubMed: 33462435DOI: 10.1038/s41564-020-00844-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.92 Å) |
Structure validation
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