6W3H
Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys
Summary for 6W3H
Entry DOI | 10.2210/pdb6w3h/pdb |
Descriptor | ATV Fc, Transferrin receptor protein 1,Transferrin receptor protein 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total) |
Functional Keywords | blood-brain barrier, transferrin binding receptor, antibody transport vehicle, protein transport |
Biological source | Homo sapiens More |
Total number of polymer chains | 4 |
Total formula weight | 88381.44 |
Authors | Srivastava, A.,Kariolis, M.,Wells, R. (deposition date: 2020-03-09, release date: 2020-06-10, Last modification date: 2023-10-18) |
Primary citation | Kariolis, M.S.,Wells, R.C.,Getz, J.A.,Kwan, W.,Mahon, C.S.,Tong, R.,Kim, D.J.,Srivastava, A.,Bedard, C.,Henne, K.R.,Giese, T.,Assimon, V.A.,Chen, X.,Zhang, Y.,Solanoy, H.,Jenkins, K.,Sanchez, P.E.,Kane, L.,Miyamoto, T.,Chew, K.S.,Pizzo, M.E.,Liang, N.,Calvert, M.E.K.,DeVos, S.L.,Baskaran, S.,Hall, S.,Sweeney, Z.K.,Thorne, R.G.,Watts, R.J.,Dennis, M.S.,Silverman, A.P.,Zuchero, Y.J.Y. Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys. Sci Transl Med, 12:-, 2020 Cited by PubMed: 32461332DOI: 10.1126/scitranslmed.aay1359 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.38 Å) |
Structure validation
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