6USF
CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor with varenicline in complex with anti-BRIL synthetic antibody BAK5
Summary for 6USF
Entry DOI | 10.2210/pdb6usf/pdb |
Related | 6CBV |
EMDB information | 20863 |
Descriptor | chimera of soluble cytochrome b562 (BRIL) and neuronal acetylcholine receptor subunit alpha-4, Neuronal acetylcholine receptor subunit beta-2, Fab heavy chain, ... (9 entities in total) |
Functional Keywords | acetylcholine receptor, nicotine, varenicline, anti-bril synthetic antibody, membrane protein, membrane protein-immune system complex, membrane protein/immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 9 |
Total formula weight | 347972.25 |
Authors | Alvarez, F.J.D.,Mukherjee, S.,Han, S.,Ammirati, M.,Kossiakoff, A.A. (deposition date: 2019-10-26, release date: 2020-04-29, Last modification date: 2020-07-29) |
Primary citation | Mukherjee, S.,Erramilli, S.K.,Ammirati, M.,Alvarez, F.J.D.,Fennell, K.F.,Purdy, M.D.,Skrobek, B.M.,Radziwon, K.,Coukos, J.,Kang, Y.,Dutka, P.,Gao, X.,Qiu, X.,Yeager, M.,Eric Xu, H.,Han, S.,Kossiakoff, A.A. Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins. Nat Commun, 11:1598-1598, 2020 Cited by PubMed: 32221310DOI: 10.1038/s41467-020-15363-0 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.87 Å) |
Structure validation
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