6U6U
IL36R extracellular domain in complex with BI655130 Fab
Summary for 6U6U
Entry DOI | 10.2210/pdb6u6u/pdb |
Descriptor | BI00655130 Fab heavy chain, BI00655130 Fab light chain, Interleukin-1 receptor-like 2, ... (7 entities in total) |
Functional Keywords | il36r, cytokine |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 70478.09 |
Authors | Larson, E.T.,Farrow, N.A. (deposition date: 2019-08-30, release date: 2020-04-22, Last modification date: 2023-10-11) |
Primary citation | Larson, E.T.,Brennan, D.L.,Hickey, E.R.,Ganesan, R.,Kroe-Barrett, R.,Farrow, N.A. X-ray crystal structure localizes the mechanism of inhibition of an IL-36R antagonist monoclonal antibody to interaction with Ig1 and Ig2 extra cellular domains. Protein Sci., 29:1679-1686, 2020 Cited by PubMed: 32239732DOI: 10.1002/pro.3862 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.31 Å) |
Structure validation
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