6Q8F

Nterminal domain of human SMU1

Summary for 6Q8F

Entry DOI	10.2210/pdb6q8f/pdb
Descriptor	WD40 repeat-containing protein SMU1, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	splicing factor, splicing
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	115592.29
Authors	Tengo, L.,Le Corre, L.,Fournier, G.,Ashraf, U.,Busca, P.,Rameix-Welti, M.-A.,Gravier-Pelletier, C.,Ruigrok, R.W.H.,Jacob, Y.,Vidalain, P.-O.,Pietrancosta, N.,Naffakh, N.,McCarthy, A.A.,Crepin, T. (deposition date: 2018-12-14, release date: 2019-05-22, Last modification date: 2019-06-12)
Primary citation	Ashraf, U.,Tengo, L.,Le Corre, L.,Fournier, G.,Busca, P.,McCarthy, A.A.,Rameix-Welti, M.A.,Gravier-Pelletier, C.,Ruigrok, R.W.H.,Jacob, Y.,Vidalain, P.O.,Pietrancosta, N.,Crepin, T.,Naffakh, N. Destabilization of the human RED-SMU1 splicing complex as a basis for host-directed antiinfluenza strategy. Proc.Natl.Acad.Sci.USA, 116:10968-10977, 2019 Cited by PubMed: 31076555 DOI: 10.1073/pnas.1901214116 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation