6ORQ
Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch antibody Ab275MUR
Summary for 6ORQ
Entry DOI | 10.2210/pdb6orq/pdb |
EMDB information | 20178 |
Descriptor | RC1 variant of HIV-1 Env glycoprotein gp41, RC1 variant of HIV-1 Env glycoprotein gp120, Ab275MUR antibody Fab heavy chain, ... (8 entities in total) |
Functional Keywords | hiv-1 broadly-neutralizing antibody, env trimer structure, v3-glycan patch, cryo-em, rc1, immunogen design, viral protein-immune system complex, antiviral protein, viral protein/immune system |
Biological source | Human immunodeficiency virus 1 More |
Total number of polymer chains | 12 |
Total formula weight | 338821.01 |
Authors | Abernathy, M.E.,Gristick, H.B.,Bjorkman, P.J. (deposition date: 2019-04-30, release date: 2019-06-12, Last modification date: 2020-07-29) |
Primary citation | Escolano, A.,Gristick, H.B.,Abernathy, M.E.,Merkenschlager, J.,Gautam, R.,Oliveira, T.Y.,Pai, J.,West Jr., A.P.,Barnes, C.O.,Cohen, A.A.,Wang, H.,Golijanin, J.,Yost, D.,Keeffe, J.R.,Wang, Z.,Zhao, P.,Yao, K.H.,Bauer, J.,Nogueira, L.,Gao, H.,Voll, A.V.,Montefiori, D.C.,Seaman, M.S.,Gazumyan, A.,Silva, M.,McGuire, A.T.,Stamatatos, L.,Irvine, D.J.,Wells, L.,Martin, M.A.,Bjorkman, P.J.,Nussenzweig, M.C. Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques. Nature, 570:468-473, 2019 Cited by PubMed: 31142836DOI: 10.1038/s41586-019-1250-z PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.4 Å) |
Structure validation
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