6NCG

Crystal Structure of Human Vaccinia-related kinase 2 (VRK-2) bound to pyridin-benzenesulfonamide inhibitor

Summary for 6NCG

• Entry DOI: 10.2210/pdb6ncg/pdb
• Descriptor: Serine/threonine-protein kinase VRK2, 4-[6-amino-5-(3,5-difluoro-4-hydroxyphenyl)pyridin-3-yl]benzene-1-sulfonamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: transferase, protein kinase domain, structural genomics, structural genomics consortium, sgc, transferase-transferase inhibitor complex
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 74427.25

Authors

dos Reis, C.V.,Chiodi, C.G.,de Souza, G.P.,Guimaraes, C.,Mascarello, A.,Gama, F.,Ferreira, M.,Counago, R.M.,Massirer, K.B.,Elkins, J.M.,Arruda, P.,Edwards, A.M.,Structural Genomics Consortium (SGC) (deposition date: 2018-12-11, release date: 2019-01-16, Last modification date: 2023-10-11)

• Primary citation: dos Reis, C.V.,Chiodi, C.G.,de Souza, G.P.,Azevedo, H.,Guimaraes, C.,Mascarello, A.,Gama, F.,Ferreira, M.,Counago, R.M.,Massirer, K.B.,Arruda, P.,Elkins, J.M.,Edwards, A.M.,Structural Genomics Consortium (SGC); Crystal Structure of Human Vaccinia-related kinase 2 (VRK-2) bound to pyridin-benzenesulfonamide inhibitor; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.45 Å)