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6MU7

Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-818251 in Complex with Human Antibodies 3H109L and 35O22 at 3.1 Angstrom

Summary for 6MU7
Entry DOI10.2210/pdb6mu7/pdb
DescriptorEnvelope glycoprotein gp160, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (13 entities in total)
Functional Keywordshiv-1 envelope prefusion trimer, entry inhibitors, immune system-inhibitor complex, immune system/inhibitor
Biological sourceHuman immunodeficiency virus 1
More
Total number of polymer chains6
Total formula weight156329.20
Authors
Lai, Y.-T.,Kwong, P.D. (deposition date: 2018-10-22, release date: 2019-01-16, Last modification date: 2020-07-29)
Primary citationLai, Y.T.,Wang, T.,O'Dell, S.,Louder, M.K.,Schon, A.,Cheung, C.S.F.,Chuang, G.Y.,Druz, A.,Lin, B.,McKee, K.,Peng, D.,Yang, Y.,Zhang, B.,Herschhorn, A.,Sodroski, J.,Bailer, R.T.,Doria-Rose, N.A.,Mascola, J.R.,Langley, D.R.,Kwong, P.D.
Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry.
Nat Commun, 10:47-47, 2019
Cited by
PubMed: 30604750
DOI: 10.1038/s41467-018-07851-1
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.501 Å)
Structure validation

217705

건을2024-03-27부터공개중

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