6MFJ
Crystal structure of the ADCC potent antibody DH677.3 Fab elicited in the RV305 vaccine trial.
Summary for 6MFJ
Entry DOI | 10.2210/pdb6mfj/pdb |
Descriptor | DH677.3 Fab heavy chain, DH677.3 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total) |
Functional Keywords | anti-hiv-1 env antibody dh677.3, cd4i antibody, adcc, hiv-1 env, immune system, rv305 vaccine trial |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 95982.91 |
Authors | Young, B.,Tolbert, W.D.,Pazgier, M. (deposition date: 2018-09-11, release date: 2019-09-25, Last modification date: 2023-10-11) |
Primary citation | Easterhoff, D.,Pollara, J.,Luo, K.,Tolbert, W.D.,Young, B.,Mielke, D.,Jha, S.,O'Connell, R.J.,Vasan, S.,Kim, J.,Michael, N.L.,Excler, J.L.,Robb, M.L.,Rerks-Ngarm, S.,Kaewkungwal, J.,Pitisuttithum, P.,Nitayaphan, S.,Sinangil, F.,Tartaglia, J.,Phogat, S.,Kepler, T.B.,Alam, S.M.,Wiehe, K.,Saunders, K.O.,Montefiori, D.C.,Tomaras, G.D.,Moody, M.A.,Pazgier, M.,Haynes, B.F.,Ferrari, G. Boosting with AIDSVAX B/E Enhances Env Constant Region 1 and 2 Antibody-Dependent Cellular Cytotoxicity Breadth and Potency. J.Virol., 94:-, 2020 Cited by PubMed: 31776278DOI: 10.1128/JVI.01120-19 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.62 Å) |
Structure validation
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