6MAC
Ternary structure of GDF11 bound to ActRIIB-ECD and Alk5-ECD
Summary for 6MAC
Entry DOI | 10.2210/pdb6mac/pdb |
Descriptor | Growth/differentiation factor 11, Activin receptor type-2B, TGF-beta receptor type-1, ... (5 entities in total) |
Functional Keywords | growth factor, receptor, tgfb, signaling, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 32901.17 |
Authors | Goebel, E.J.,Thompson, T.B. (deposition date: 2018-08-27, release date: 2019-07-17, Last modification date: 2023-10-11) |
Primary citation | Goebel, E.J.,Corpina, R.A.,Hinck, C.S.,Czepnik, M.,Castonguay, R.,Grenha, R.,Boisvert, A.,Miklossy, G.,Fullerton, P.T.,Matzuk, M.M.,Idone, V.J.,Economides, A.N.,Kumar, R.,Hinck, A.P.,Thompson, T.B. Structural characterization of an activin class ternary receptor complex reveals a third paradigm for receptor specificity. Proc.Natl.Acad.Sci.USA, 116:15505-15513, 2019 Cited by PubMed: 31315975DOI: 10.1073/pnas.1906253116 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.34 Å) |
Structure validation
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