6M3B
hAPC-c25k23 Fab complex
Summary for 6M3B
Entry DOI | 10.2210/pdb6m3b/pdb |
Descriptor | Vitamin K-dependent protein C heavy chain, Vitamin K-dependent protein C light chain, c25k23 Fab L chain, ... (6 entities in total) |
Functional Keywords | human apc, c25k23 fab, complex, blood clotting, blood clotting-immune system complex, blood clotting/immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 92505.03 |
Authors | |
Primary citation | Zhao, X.Y.,Wilmen, A.,Wang, D.,Wang, X.,Bauzon, M.,Kim, J.Y.,Linden, L.,Li, L.,Egner, U.,Marquardt, T.,Moosmayer, D.,Tebbe, J.,Gluck, J.M.,Ellinger, P.,McLean, K.,Yuan, S.,Yegneswaran, S.,Jiang, X.,Evans, V.,Gu, J.M.,Schneider, D.,Zhu, Y.,Xu, Y.,Mallari, C.,Hesslein, A.,Wang, Y.,Schmidt, N.,Gutberlet, K.,Ruehl-Fehlert, C.,Freyberger, A.,Hermiston, T.,Patel, C.,Sim, D.,Mosnier, L.O.,Laux, V. Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia. Nat Commun, 11:2992-2992, 2020 Cited by PubMed: 32532974DOI: 10.1038/s41467-020-16720-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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