6JR3
Crystal structure of insulin hexamer fitted into cryo EM density map where each dimer was kept as rigid body
Summary for 6JR3
| Entry DOI | 10.2210/pdb6jr3/pdb |
| EMDB information | 9878 |
| Descriptor | Insulin A chain, Insulin B chain (2 entities in total) |
| Functional Keywords | insulin fibrillation, natural polyphenols, anti-amyloid activity, insulin hexamer, bioavailability, hormone |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 12 |
| Total formula weight | 34905.91 |
| Authors | Sengupta, J.,Pathak, B.K.,Bhakta, S. (deposition date: 2019-04-02, release date: 2020-04-22, Last modification date: 2024-03-27) |
| Primary citation | Pathak, B.K.,Das, D.,Bhakta, S.,Chakrabarti, P.,Sengupta, J. Resveratrol as a nontoxic excipient stabilizes insulin in a bioactive hexameric form. J.Comput.Aided Mol.Des., 34:915-927, 2020 Cited by PubMed: 32270361DOI: 10.1007/s10822-020-00311-3 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (14.5 Å) |
Structure validation
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