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6GTG

Transition state structure of Cpf1(Cas12a) I4 conformation

Summary for 6GTG
Entry DOI10.2210/pdb6gtg/pdb
EMDB information0065
DescriptorCRISPR-associated endonuclease Cas12a, RNA (40-MER), DNA (32-MER), ... (6 entities in total)
Functional Keywordsgenome editing crispr ribonucleoprotein complex, hydrolase
Biological sourceFrancisella tularensis subsp. novicida U112
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Total number of polymer chains4
Total formula weight203377.96
Authors
Mesa, P.,Montoya, G.,Stella, S. (deposition date: 2018-06-18, release date: 2018-12-19, Last modification date: 2019-12-18)
Primary citationStella, S.,Mesa, P.,Thomsen, J.,Paul, B.,Alcon, P.,Jensen, S.B.,Saligram, B.,Moses, M.E.,Hatzakis, N.S.,Montoya, G.
Conformational Activation Promotes CRISPR-Cas12a Catalysis and Resetting of the Endonuclease Activity.
Cell, 175:1856-1871.e21, 2018
Cited by
PubMed: 30503205
DOI: 10.1016/j.cell.2018.10.045
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (3.27 Å)
Structure validation

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