6FG2
CRYSTAL STRUCTURE OF FAB OF NATALIZUMAB IN COMPLEX WITH FAB OF NAA84.
Summary for 6FG2
Entry DOI | 10.2210/pdb6fg2/pdb |
Descriptor | HEAVY CHAIN FAB NAA84, LIGHT CHAIN FAB NAA84, HEAVY CHAIN FAB NATALIZUMAB, ... (5 entities in total) |
Functional Keywords | antibody, immune system |
Biological source | Homo sapiens (HUMAN) More |
Total number of polymer chains | 8 |
Total formula weight | 195444.96 |
Authors | Bertrand, T.,Pouzieux, S. (deposition date: 2018-01-09, release date: 2019-07-24, Last modification date: 2024-01-17) |
Primary citation | Cassotta, A.,Mikol, V.,Bertrand, T.,Pouzieux, S.,Le Parc, J.,Ferrari, P.,Dumas, J.,Auer, M.,Deisenhammer, F.,Gastaldi, M.,Franciotta, D.,Silacci-Fregni, C.,Fernandez Rodriguez, B.,Giacchetto-Sasselli, I.,Foglierini, M.,Jarrossay, D.,Geiger, R.,Sallusto, F.,Lanzavecchia, A.,Piccoli, L. A single T cell epitope drives the neutralizing anti-drug antibody response to natalizumab in multiple sclerosis patients. Nat. Med., 25:1402-1407, 2019 Cited by PubMed: 31501610DOI: 10.1038/s41591-019-0568-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.788 Å) |
Structure validation
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