6F0E

Structure of yeast Sec14p with a picolinamide compound

Summary for 6F0E

Entry DOI	10.2210/pdb6f0e/pdb
Descriptor	SEC14 cytosolic factor, ~{N}-(1,3-benzodioxol-5-ylmethyl)-5-bromanyl-3-fluoranyl-pyridine-2-carboxamide (3 entities in total)
Functional Keywords	sec14p, lipid transfer protein, chemogenomics, target identification, functional variomics, co-crystal, antifungal, benzamide, picolinamide, lipid binding protein
Biological source	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Cellular location	Golgi apparatus membrane; Peripheral membrane protein: P24280
Total number of polymer chains	1
Total formula weight	36401.02
Authors	Hong, Z.,Johnen, P.,Schaaf, G.,Bono, F. (deposition date: 2017-11-20, release date: 2018-01-17, Last modification date: 2024-01-17)
Primary citation	Pries, V.,Nocker, C.,Khan, D.,Johnen, P.,Hong, Z.,Tripathi, A.,Keller, A.L.,Fitz, M.,Perruccio, F.,Filipuzzi, I.,Thavam, S.,Aust, T.,Riedl, R.,Ziegler, S.,Bono, F.,Schaaf, G.,Bankaitis, V.A.,Waldmann, H.,Hoepfner, D. Target Identification and Mechanism of Action of Picolinamide and Benzamide Chemotypes with Antifungal Properties. Cell Chem Biol, 25:279-290.e7, 2018 Cited by PubMed: 29307839 DOI: 10.1016/j.chembiol.2017.12.007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation