6EO6
X-ray structure of the complex between human alpha-thrombin and modified 15-mer DNA aptamer containing 5-(3-(2-(1H-indol-3-yl)acetamide-N-yl)-1-propen-1-yl)-2'-deoxyuridine residue
Replaces: 5LUWSummary for 6EO6
Entry DOI | 10.2210/pdb6eo6/pdb |
Related PRD ID | PRD_000020 |
Descriptor | GA63A - TBA MODIFIED APTAMER, Prothrombin, POTASSIUM ION, ... (8 entities in total) |
Functional Keywords | alpha thrombin, aptamer, thrombin-mtba, complex, hydrolase-dna complex, hydrolase/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 39555.31 |
Authors | Dolot, R.M.,Nawrot, B.,Yang, X. (deposition date: 2017-10-09, release date: 2017-10-25, Last modification date: 2024-01-17) |
Primary citation | Dolot, R.,Lam, C.H.,Sierant, M.,Zhao, Q.,Liu, F.W.,Nawrot, B.,Egli, M.,Yang, X. Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity. Nucleic Acids Res., 46:4819-4830, 2018 Cited by PubMed: 29684204DOI: 10.1093/nar/gky268 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.69 Å) |
Structure validation
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