6E1A

Menin bound to M-89

Summary for 6E1A

Entry DOI	10.2210/pdb6e1a/pdb
Descriptor	Menin, (1S,2R)-2-[(4S)-2-methyl-4-{1-[(1-{4-[(pyridin-4-yl)sulfonyl]phenyl}azetidin-3-yl)methyl]piperidin-4-yl}-1,2,3,4-tetrahydroisoquinolin-4-yl]cyclopentyl methylcarbamate, praseodymium triacetate, ... (4 entities in total)
Functional Keywords	inhibitor, protein binding, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	63309.30
Authors	Stuckey, J.A. (deposition date: 2018-07-09, release date: 2019-07-10, Last modification date: 2023-10-11)
Primary citation	Aguilar, A.,Zheng, K.,Xu, T.,Xu, S.,Huang, L.,Fernandez-Salas, E.,Liu, L.,Bernard, D.,Harvey, K.P.,Foster, C.,McEachern, D.,Stuckey, J.,Chinnaswamy, K.,Delproposto, J.,Kampf, J.W.,Wang, S. Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction. J.Med.Chem., 62:6015-6034, 2019 Cited by PubMed: 31244110 DOI: 10.1021/acs.jmedchem.9b00021 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation