6BIT
SIRPalpha antibody complex
Summary for 6BIT
Entry DOI | 10.2210/pdb6bit/pdb |
Descriptor | KWAR23 Fab heavy chain, KWAR23 Fab light chain, Tyrosine-protein phosphatase non-receptor type substrate 1, ... (4 entities in total) |
Functional Keywords | macrophage, neutrophil, phagocytosis, myeloid, immune checkpoint, cd47, sirp, cancer immunotherapy, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 117590.84 |
Authors | Ring, N.G.,Herndler-Brandstetter, D.,Weiskopf, K.,Shan, L.,Volkmer, J.P.,George, B.M.,Lietzenmayer, M.,McKenna, K.M.,Naik, T.J.,McCarty, A.,Zheng, Y.,Ring, A.M.,Flavell, R.A.,Weissman, I.L. (deposition date: 2017-11-03, release date: 2017-12-06, Last modification date: 2019-11-20) |
Primary citation | Ring, N.G.,Herndler-Brandstetter, D.,Weiskopf, K.,Shan, L.,Volkmer, J.P.,George, B.M.,Lietzenmayer, M.,McKenna, K.M.,Naik, T.J.,McCarty, A.,Zheng, Y.,Ring, A.M.,Flavell, R.A.,Weissman, I.L. Anti-SIRP alpha antibody immunotherapy enhances neutrophil and macrophage antitumor activity. Proc. Natl. Acad. Sci. U.S.A., 114:E10578-E10585, 2017 Cited by PubMed: 29158380DOI: 10.1073/pnas.1710877114 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.191 Å) |
Structure validation
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