6ARX
Crystal structure of an insecticide-resistant acetylcholinesterase mutant from the malaria vector Anopheles gambiae in the ligand-free state
Summary for 6ARX
Entry DOI | 10.2210/pdb6arx/pdb |
Descriptor | Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose, CITRATE ANION, ... (5 entities in total) |
Functional Keywords | hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Anopheles gambiae (African malaria mosquito) |
Cellular location | Cell junction, synapse: Q869C3 |
Total number of polymer chains | 2 |
Total formula weight | 122691.41 |
Authors | Cheung, J.,Mahmood, A.,Kalathur, R.,Lixuan, L.,Carlier, P.R. (deposition date: 2017-08-23, release date: 2018-01-10, Last modification date: 2023-10-04) |
Primary citation | Cheung, J.,Mahmood, A.,Kalathur, R.,Liu, L.,Carlier, P.R. Structure of the G119S Mutant Acetylcholinesterase of the Malaria Vector Anopheles gambiae Reveals Basis of Insecticide Resistance. Structure, 26:130-136.e2, 2018 Cited by PubMed: 29276037DOI: 10.1016/j.str.2017.11.021 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.302 Å) |
Structure validation
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