5ZYL

Crystal structure of CERT START domain in complex with compound E25A

Summary for 5ZYL

Related5ZYG 5ZYH 5ZYI 5ZYJ 5ZYK 5ZYM
DescriptorLIPID-TRANSFER PROTEIN CERT, 2-[4-[4-cyclopentyl-3-[(1~{S},2~{R})-2-pyridin-2-ylcyclopropyl]phenyl]phenyl]sulfonylethanol, GLYCEROL, ... (4 entities in total)
Functional Keywordscert, ph, start, complex, lipid transport
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight27596.46
Authors
Suzuki, M.,Nakao, N.,Ueno, M.,Sakai, S.,Egawa, D.,Hanzawa, H.,Kawasaki, S.,Kumagai, K.,Kobayashi, S.,Hanada, K. (deposition date: 2018-05-25, release date: 2019-02-27, Last modification date: 2019-03-06)
Primary citation
Nakao, N.,Ueno, M.,Sakai, S.,Egawa, D.,Hanzawa, H.,Kawasaki, S.,Kumagai, K.,Suzuki, M.,Kobayashi, S.,Hanada, K.
Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT
Commun Chem, 2019
DOI: 10.1038/s42004-019-0118-3
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.22410 0.4% 2.9% 3.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5zyl
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Molmil generated image of 5zyl
rotated about x axis by 90°
Molmil generated image of 5zyl
rotated about y axis by 90°