Crystal Structure of the Human Coronavirus 229E HR1 motif in complex with pan-CoVs inhibitor EK1

Summary for 5ZUV

DescriptorSpike glycoprotein,Spike glycoprotein,inhibitor EK1, CHLORIDE ION (3 entities in total)
Functional Keywordshuman coronavirus 229e, spike protein, s2 domain, hr1 motif, pan-coronavirus, viral protein, inhibitor
Biological sourceHuman coronavirus 229E (HCoV-229E)
Total number of polymer chains3
Total molecular weight44141.94
Yan, L.,Yang, B.,Wilson, I.A. (deposition date: 2018-05-08, release date: 2019-04-10, Last modification date: 2019-04-17)
Primary citation
Xia, S.,Yan, L.,Xu, W.,Agrawal, A.S.,Algaissi, A.,Tseng, C.T.K.,Wang, Q.,Du, L.Y.,Wilson, I.A.,Jiang, S.B.,Yang, B.,Lu, L.
A Pan-coronavirus Fusion Inhibitor against Human Coronavirus Infection in Respiratory Tract
To Be Published,
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.24920 1.2% 4.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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