5ZRF

Crystal structure of human topoisomerase II beta in complex with 5-iodouridine-containing-DNA and etoposide in space group p21

Summary for 5ZRF

• Entry DOI: 10.2210/pdb5zrf/pdb
• Descriptor: DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA/RNA (5'-R(P*(IU))-D(P*GP*CP*AP*GP*C)-R(P*(IU))-D(P*CP*GP*GP*C)-R(P*(IU))-3'), ... (6 entities in total)
• Functional Keywords: type ii topoisomerase, anti-cancer drug, topoii cleavage complex, isomerase-dna complex, isomerase-dna-isomerase inhibitor complex, isomerase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 198128.89

Authors

Chen, S.F.,Wang, Y.R.,Wu, C.C.,Chan, N.L. (deposition date: 2018-04-24, release date: 2018-08-08, Last modification date: 2023-11-22)

• Primary citation: Chen, S.F.,Huang, N.L.,Lin, J.H.,Wu, C.C.,Wang, Y.R.,Yu, Y.J.,Gilson, M.K.,Chan, N.L.; Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate.; Nat Commun, 9:3085-3085, 2018; PubMed: 30082834; DOI: 10.1038/s41467-018-05406-y

Experimental method

X-RAY DIFFRACTION (2.3 Å)