5ZRF

Crystal structure of human topoisomerase II beta in complex with 5-iodouridine-containing-DNA and etoposide in space group p21

5ZRF の概要

• エントリーDOI: 10.2210/pdb5zrf/pdb
• 分子名称: DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA/RNA (5'-R(P*(IU))-D(P*GP*CP*AP*GP*C)-R(P*(IU))-D(P*CP*GP*GP*C)-R(P*(IU))-3'), ... (6 entities in total)
• 機能のキーワード: type ii topoisomerase, anti-cancer drug, topoii cleavage complex, isomerase-dna complex, isomerase-dna-isomerase inhibitor complex, isomerase/dna
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 198128.89

構造登録者

Chen, S.F.,Wang, Y.R.,Wu, C.C.,Chan, N.L. (登録日: 2018-04-24, 公開日: 2018-08-08, 最終更新日: 2023-11-22)

• 主引用文献: Chen, S.F.,Huang, N.L.,Lin, J.H.,Wu, C.C.,Wang, Y.R.,Yu, Y.J.,Gilson, M.K.,Chan, N.L.; Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate.; Nat Commun, 9:3085-3085, 2018; PubMed: 30082834; DOI: 10.1038/s41467-018-05406-y

実験手法

X-RAY DIFFRACTION (2.3 Å)