5ZM8

Crystal structure of ORP2-ORD in complex with PI(4,5)P2

Summary for 5ZM8

• Entry DOI: 10.2210/pdb5zm8/pdb
• Descriptor: Oxysterol-binding protein-related protein 2, [(2~{S})-1-octadecanoyloxy-3-[oxidanyl-[(1~{R},2~{R},3~{S},4~{S},5~{S},6~{S})-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] icosa-5,8,11,14-tetraenoate (3 entities in total)
• Functional Keywords: transporter, complex, phospholipid, lipid transport
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 107641.47

Authors

Wang, H.,Dong, J.Q.,Wang, J.,Wu, J.W. (deposition date: 2018-04-01, release date: 2019-01-02, Last modification date: 2023-11-22)

• Primary citation: Wang, H.,Ma, Q.,Qi, Y.,Dong, J.,Du, X.,Rae, J.,Wang, J.,Wu, W.F.,Brown, A.J.,Parton, R.G.,Wu, J.W.,Yang, H.; ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P2).; Mol. Cell, 73:458-473.e7, 2019; PubMed: 30581148; DOI: 10.1016/j.molcel.2018.11.014

Experimental method

X-RAY DIFFRACTION (2.7 Å)