5ZHE

STRUCTURE OF E. COLI UNDECAPRENYL DIPHOSPHATE SYNTHASE IN COMPLEX WITH BPH-981

5ZHE の概要

• エントリーDOI: 10.2210/pdb5zhe/pdb
• 分子名称: Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific), 2-hydroxy-6-(tetradecyloxy)benzoic acid (3 entities in total)
• 機能のキーワード: metal-binding, substrate binding, acidocalcisomal pyrophosphatase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Escherichia coli K-12
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 57312.75

構造登録者

Gao, J.,Liu, W.D.,Zheng, Y.Y.,Ko, T.P.,Chen, C.C.,Guo, R.T. (登録日: 2018-03-13, 公開日: 2019-03-13, 最終更新日: 2023-11-22)

• 主引用文献: Malwal, S.R.,Chen, L.,Hicks, H.,Qu, F.,Liu, W.,Shillo, A.,Law, W.X.,Zhang, J.,Chandnani, N.,Han, X.,Zheng, Y.,Chen, C.C.,Guo, R.T.,AbdelKhalek, A.,Seleem, M.N.,Oldfield, E.; Discovery of Lipophilic Bisphosphonates That Target Bacterial Cell Wall and Quinone Biosynthesis.; J.Med.Chem., 62:2564-2581, 2019; PubMed: 30730737; DOI: 10.1021/acs.jmedchem.8b01878

実験手法

X-RAY DIFFRACTION (2.18 Å)