5ZGE

Crystal structure of NDM-1 at pH5.5 (Bis-Tris) in complex with hydrolyzed ampicillin

Replaces:  3Q6X

Summary for 5ZGE

• Entry DOI: 10.2210/pdb5zge/pdb
• Descriptor: Metallo-beta-lactamase type 2, (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, ZINC ION, ... (5 entities in total)
• Functional Keywords: ndm-1, metallo-beta-lactamase, antibiotic resistent, conformational change, antibiotic, hydrolase-antibiotic complex, hydrolase/antibiotic
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 2
• Total formula weight: 52294.13

Authors

Zhang, H.,Hao, Q. (deposition date: 2018-03-08, release date: 2018-08-22, Last modification date: 2023-11-22)

• Primary citation: Zhang, H.,Ma, G.,Zhu, Y.,Zeng, L.,Ahmad, A.,Wang, C.,Pang, B.,Fang, H.,Zhao, L.,Hao, Q.; Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1.; Antimicrob. Agents Chemother., 62:-, 2018; PubMed: 30150473; DOI: 10.1128/AAC.01579-18

Experimental method

X-RAY DIFFRACTION (1 Å)