5ZG3

Crystal structure of the GluA2o LBD in complex with glutamate and TAK-137

Summary for 5ZG3

• Entry DOI: 10.2210/pdb5zg3/pdb
• Descriptor: Glutamate receptor 2, 9-(4-phenoxyphenyl)-3,4-dihydro-2H-2lambda~6~-pyrido[2,1-c][1,2,4]thiadiazine-2,2-dione, GLUTAMIC ACID, ... (6 entities in total)
• Functional Keywords: ampa receptor ligand-binding domain, allosteric modulation complex, membrane protein, transport protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 179401.37

Authors

Sogabe, S.,Igaki, S.,Hirokawa, A.,Zama, Y.,Lane, W.,Snell, G. (deposition date: 2018-03-07, release date: 2019-01-16, Last modification date: 2023-11-22)

• Primary citation: Kunugi, A.,Tanaka, M.,Suzuki, A.,Tajima, Y.,Suzuki, N.,Suzuki, M.,Nakamura, S.,Kuno, H.,Yokota, A.,Sogabe, S.,Kosugi, Y.,Awasaki, Y.,Kaku, T.,Kimura, H.; TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window.; Neuropsychopharmacology, 44:961-970, 2019; PubMed: 30209408; DOI: 10.1038/s41386-018-0213-7

Experimental method

X-RAY DIFFRACTION (1.65 Å)