5ZFL

Crystal structure of beta-lactamase PenP mutant E166Y

Summary for 5ZFL

• Entry DOI: 10.2210/pdb5zfl/pdb
• Descriptor: Beta-lactamase, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: class a beta-lactamase, antibiotic resistance, hydrolase
• Biological source: Bacillus licheniformis
• Total number of polymer chains: 2
• Total formula weight: 60801.07

Authors

Pan, X.,Zhao, Y. (deposition date: 2018-03-06, release date: 2019-03-20, Last modification date: 2023-11-22)

• Primary citation: He, Y.,Lei, J.,Pan, X.,Huang, X.,Zhao, Y.; The hydrolytic water molecule of Class A beta-lactamase relies on the acyl-enzyme intermediate ES* for proper coordination and catalysis.; Sci Rep, 10:10205-10205, 2020; PubMed: 32576842; DOI: 10.1038/s41598-020-66431-w

Experimental method

X-RAY DIFFRACTION (1.5 Å)