5ZBZ
Crystal structure of the DEAD domain of Human eIF4A with sanguinarine
Summary for 5ZBZ
Entry DOI | 10.2210/pdb5zbz/pdb |
Descriptor | Eukaryotic initiation factor 4A-I, 13-methyl[1,3]benzodioxolo[5,6-c][1,3]dioxolo[4,5-i]phenanthridin-13-ium, MALONATE ION, ... (4 entities in total) |
Functional Keywords | eukaryotic translation initiation factor 4a, sanguinarine, inhibitor, translation, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 25360.47 |
Authors | |
Primary citation | Jiang, C.,Tang, Y.,Ding, L.,Tan, R.,Li, X.,Lu, J.,Jiang, J.,Cui, Z.,Tang, Z.,Li, W.,Cao, Z.,Schneider-Poetsch, T.,Jiang, W.,Luo, C.,Ding, Y.,Liu, J.,Dang, Y. Targeting the N Terminus of eIF4AI for Inhibition of Its Catalytic Recycling. Cell Chem Biol, 26:1417-1426.e5, 2019 Cited by PubMed: 31402318DOI: 10.1016/j.chembiol.2019.07.010 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.30860259206 Å) |
Structure validation
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