5ZAN

Crystal Structure of Aurora-A in complex with a new Quinazoline inhibitor

Summary for 5ZAN

• Entry DOI: 10.2210/pdb5zan/pdb
• Descriptor: Aurora kinase A, 7-(4-methylpiperazin-1-yl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(E)-2-phenylethenyl]quinazolin-4-amine (2 entities in total)
• Functional Keywords: drug design, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 32985.88

Authors

Cheng, B.,Lu, G.,Zhou, H. (deposition date: 2018-02-07, release date: 2019-02-13, Last modification date: 2023-11-22)

• Primary citation: Long, L.,Peng, W.,Pan, Y.,Cheng, B.,Tu, Z.,Long, Z.,Zhou, H.,Liu, Q.,Lu, G.; Optimization of Novel Quinazolines as Potent and Orally Bioavailable Aurora Kinase Inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.85 Å)