5YTZ

Crystal structure of echinomycin-d(ACGTCGT)2 complex

Summary for 5YTZ

• Entry DOI: 10.2210/pdb5ytz/pdb
• Related PRD ID: PRD_000491
• Descriptor: DNA (5'-D(P*AP*CP*GP*TP*CP*GP*(UD))-3'), Echinomycin, MANGANESE (II) ION, ... (6 entities in total)
• Functional Keywords: echinomycin, dna intercalator, antibiotic, echinomycin-dna complex, mismatched base pairs, t-t mismatch, pyrimidine-pyrimidine base pairing, dna mismatch repair (mmr), non-canonical duplex structure, antibiotic-dna complex, antibiotic/dna
• Biological source: Streptomyces echinatus; More
• Total number of polymer chains: 4
• Total formula weight: 6820.17

Authors

Hou, M.H.,Wu, P.C.,Kao, Y.F. (deposition date: 2017-11-20, release date: 2018-05-23, Last modification date: 2023-11-22)

• Primary citation: Wu, P.C.,Tzeng, S.L.,Chang, C.K.,Kao, Y.F.,Waring, M.J.,Hou, M.H.; Cooperative recognition of T:T mismatch by echinomycin causes structural distortions in DNA duplex; Nucleic Acids Res., 46:7396-7404, 2018; PubMed: 29741655; DOI: 10.1093/nar/gky345

Experimental method

X-RAY DIFFRACTION (1.55 Å)