5YOY

Crystal structure of the human tumor necrosis factor in complex with golimumab Fv

Summary for 5YOY

• Entry DOI: 10.2210/pdb5yoy/pdb
• Descriptor: Tumor necrosis factor, Golimumab light chain variable region, Golimumab heavy chain variable region, ... (4 entities in total)
• Functional Keywords: cytokine, antibody, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 18
• Total formula weight: 279323.32

Authors

Ono, M.,Horita, S.,Sato, Y.,Nomura, Y.,Iwata, S.,Nomura, N. (deposition date: 2017-10-31, release date: 2018-05-09, Last modification date: 2023-11-22)

• Primary citation: Ono, M.,Horita, S.,Sato, Y.,Nomura, Y.,Iwata, S.,Nomura, N.; Structural basis for tumor necrosis factor blockade with the therapeutic antibody golimumab; Protein Sci., 27:1038-1046, 2018; PubMed: 29575262; DOI: 10.1002/pro.3407

Experimental method

X-RAY DIFFRACTION (2.727 Å)