5YKP

Human methionine aminopeptidase type 1b (F309M mutant) in complex with ovalicin

Summary for 5YKP

Entry DOI	10.2210/pdb5ykp/pdb
Descriptor	Methionine aminopeptidase 1, COBALT (II) ION, POTASSIUM ION, ... (5 entities in total)
Functional Keywords	selective inhibition, streptococcal pneumoniae, enterococcus feacalis, metal binding protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	34774.31
Authors	Arya, T.,Pillalamarri, V.,Addlagatta, A. (deposition date: 2017-10-15, release date: 2018-10-17, Last modification date: 2023-11-22)
Primary citation	Pillalamarri, V.,Arya, T.,Haque, N.,Bala, S.C.,Marapaka, A.K.,Addlagatta, A. Discovery of natural product ovalicin sensitive type 1 methionine aminopeptidases: molecular and structural basis. Biochem. J., 476:991-1003, 2019 Cited by PubMed: 30837307 DOI: 10.1042/BCJ20180874 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.68 Å)

Structure validation