5YHL

Crystal structure of the human prostaglandin E receptor EP4 in complex with Fab and an antagonist Br-derivative

Summary for 5YHL

• Entry DOI: 10.2210/pdb5yhl/pdb
• Related: 5WV2 5YFI
• Descriptor: Prostaglandin E2 receptor EP4 subtype, Heavy chain of Fab fragment, Light chain of Fab fragment, ... (4 entities in total)
• Functional Keywords: g-protein coupled receptor, lipid mediator, functional antibody, signaling protein-immune system complex, signaling protein/immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 91717.84

Authors

Toyoda, Y.,Morimoto, K.,Suno, R.,Horita, S.,Iwata, S.,Kobayashi, T. (deposition date: 2017-09-28, release date: 2018-12-05, Last modification date: 2023-11-22)

• Primary citation: Toyoda, Y.,Morimoto, K.,Suno, R.,Horita, S.,Yamashita, K.,Hirata, K.,Sekiguchi, Y.,Yasuda, S.,Shiroishi, M.,Shimizu, T.,Urushibata, Y.,Kajiwara, Y.,Inazumi, T.,Hotta, Y.,Asada, H.,Nakane, T.,Shiimura, Y.,Nakagita, T.,Tsuge, K.,Yoshida, S.,Kuribara, T.,Hosoya, T.,Sugimoto, Y.,Nomura, N.,Sato, M.,Hirokawa, T.,Kinoshita, M.,Murata, T.,Takayama, K.,Yamamoto, M.,Narumiya, S.,Iwata, S.,Kobayashi, T.; Ligand binding to human prostaglandin E receptor EP4at the lipid-bilayer interface.; Nat. Chem. Biol., 15:18-26, 2019; PubMed: 30510193; DOI: 10.1038/s41589-018-0131-3

Experimental method

X-RAY DIFFRACTION (4.2 Å)