5YA5

CRYSTAL STRUCTURE OF c-MET IN COMPLEX WITH NOVEL INHIBITOR

Summary for 5YA5

• Entry DOI: 10.2210/pdb5ya5/pdb
• Descriptor: Hepatocyte growth factor receptor, 2-[3-(4-methoxybenzyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]-1H-indole (3 entities in total)
• Functional Keywords: c-met inhibitor, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 36395.01

Authors

Liu, Q.,Xu, Y. (deposition date: 2017-08-30, release date: 2018-07-04, Last modification date: 2023-11-22)

• Primary citation: Yuan, H.,Liu, Q.,Zhang, L.,Hu, S.,Chen, T.,Li, H.,Chen, Y.,Xu, Y.,Lu, T.; Discovery, optimization and biological evaluation for novel c-Met kinase inhibitors; Eur J Med Chem, 143:491-502, 2018; PubMed: 29202410; DOI: 10.1016/j.ejmech.2017.11.073

Experimental method

X-RAY DIFFRACTION (1.89 Å)