5XXH

Crystal Structure Analysis of the CBP

5XXH の概要

• エントリーDOI: 10.2210/pdb5xxh/pdb
• 分子名称: CREB-binding protein, (3S)-1-[2-(3-ethanoylindol-1-yl)ethanoyl]piperidine-3-carboxylic acid, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: cbp, bromodomain, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 16306.03

構造登録者

Xiang, Q.,Zhang, Y.,Wang, C.,Song, M. (登録日: 2017-07-04, 公開日: 2018-06-13, 最終更新日: 2023-11-22)

• 主引用文献: Xiang, Q.,Wang, C.,Zhang, Y.,Xue, X.,Song, M.,Zhang, C.,Li, C.,Wu, C.,Li, K.,Hui, X.,Zhou, Y.,Smaill, J.B.,Patterson, A.V.,Wu, D.,Ding, K.,Xu, Y.; Discovery and optimization of 1-(1H-indol-1-yl)ethanone derivatives as CBP/EP300 bromodomain inhibitors for the treatment of castration-resistant prostate cancer.; Eur J Med Chem, 147:238-252, 2018; PubMed: 29448139; DOI: 10.1016/j.ejmech.2018.01.087

実験手法

X-RAY DIFFRACTION (1.62 Å)