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5XPR

Human endothelin receptor type-B in complex with antagonist bosentan

Summary for 5XPR
Entry DOI10.2210/pdb5xpr/pdb
DescriptorEndothelin B receptor,Endolysin,Endothelin B receptor, 4-tert-butyl-N-[6-(2-hydroxyethyloxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-pyrimidin-4-yl]benzenesulfonamide, SULFATE ION (3 entities in total)
Functional Keywordsalpha helical, signaling protein
Biological sourceHomo sapiens (Human)
More
Cellular locationCell membrane ; Multi-pass membrane protein: P24530
Total number of polymer chains1
Total formula weight53063.96
Authors
Shihoya, W.,Nishizawa, T.,Yamashita, K.,Hirata, K.,Okuta, A.,Tani, K.,Fujiyoshi, Y.,Doi, T.,Nureki, O. (deposition date: 2017-06-04, release date: 2017-08-16, Last modification date: 2017-11-15)
Primary citationShihoya, W.,Nishizawa, T.,Yamashita, K.,Inoue, A.,Hirata, K.,Kadji, F.M.N.,Okuta, A.,Tani, K.,Aoki, J.,Fujiyoshi, Y.,Doi, T.,Nureki, O.
X-ray structures of endothelin ETB receptor bound to clinical antagonist bosentan and its analog
Nat. Struct. Mol. Biol., 24:758-764, 2017
Cited by
PubMed: 28805809
DOI: 10.1038/nsmb.3450
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.6 Å)
Structure validation

217705

數據於2024-03-27公開中

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