5X94

Crystal structure of SHP2_SH2-CagA EPIYA_D peptide complex

Summary for 5X94

• Entry DOI: 10.2210/pdb5x94/pdb
• Related: 5X7B
• Descriptor: Tyrosine-protein phosphatase non-receptor type 11, Cag pathogenicity island protein (3 entities in total)
• Functional Keywords: helicobacter pylori caga, sh2 domain-containing protein tyrosine phosphatase 2 (shp2), caga polymorphism, hydrolase
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm : Q06124
• Total number of polymer chains: 6
• Total formula weight: 56087.02

Authors

Senda, M.,Senda, T. (deposition date: 2017-03-05, release date: 2017-09-13, Last modification date: 2023-11-22)

• Primary citation: Hayashi, T.,Senda, M.,Suzuki, N.,Nishikawa, H.,Ben, C.,Tang, C.,Nagase, L.,Inoue, K.,Senda, T.,Hatakeyama, M.; Differential Mechanisms for SHP2 Binding and Activation Are Exploited by Geographically Distinct Helicobacter pylori CagA Oncoproteins.; Cell Rep, 20:2876-2890, 2017; PubMed: 28930683; DOI: 10.1016/j.celrep.2017.08.080

Experimental method

X-RAY DIFFRACTION (2.6 Å)