6LK4

Crystal structure of GMP reductase from Trypanosoma brucei in complex with guanosine 5'-triphosphate

Replaces:  5X8O

Summary for 6LK4

• Entry DOI: 10.2210/pdb6lk4/pdb
• Descriptor: Guanosine 5'-monophosphate Reductase, GUANOSINE-5'-TRIPHOSPHATE, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: trypanosoma brucei, 5'-monophosphate reductase, guanosine 5'-triphosphate, cystathionine beta synthase motif, oxidoreductase
• Biological source: Trypanosoma brucei brucei
• Total number of polymer chains: 1
• Total formula weight: 54456.39

Authors

Mase, H.,Otani, T.,Imamura, A.,Nishimura, S.,Inui, T. (deposition date: 2019-12-18, release date: 2020-03-18, Last modification date: 2023-11-22)

• Primary citation: Imamura, A.,Okada, T.,Mase, H.,Otani, T.,Kobayashi, T.,Tamura, M.,Kubata, B.K.,Inoue, K.,Rambo, R.P.,Uchiyama, S.,Ishii, K.,Nishimura, S.,Inui, T.; Allosteric regulation accompanied by oligomeric state changes of Trypanosoma brucei GMP reductase through cystathionine-beta-synthase domain.; Nat Commun, 11:1837-1837, 2020; PubMed: 32296055; DOI: 10.1038/s41467-020-15611-3

Experimental method

X-RAY DIFFRACTION (2.503 Å)