5WVE

Apaf-1-Caspase-9 holoenzyme

Summary for 5WVE

• Entry DOI: 10.2210/pdb5wve/pdb
• EMDB information: 6690
• Descriptor: Apoptotic protease-activating factor 1, Cytochrome c, Caspase, ... (7 entities in total)
• Functional Keywords: apoptosis holoenzyme, apoptosis
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm : O14727 O14727; Mitochondrion intermembrane space: P00004
• Total number of polymer chains: 25
• Total formula weight: 1213030.43

Authors

Li, Y.,Zhou, M.,Hu, Q.,Shi, Y. (deposition date: 2016-12-24, release date: 2017-02-08, Last modification date: 2017-03-01)

• Primary citation: Li, Y.,Zhou, M.,Hu, Q.,Bai, X.-C.,Huang, W.,Scheres, S.H.W.,Shi, Y.; Mechanistic insights into caspase-9 activation by the structure of the apoptosome holoenzyme; Proc. Natl. Acad. Sci. U.S.A., 114:1542-1547, 2017; PubMed: 28143931; DOI: 10.1073/pnas.1620626114

Experimental method

ELECTRON MICROSCOPY (4.4 Å)