5WQC

Crystal structure of human orexin 2 receptor bound to the selective antagonist EMPA determined by the synchrotron light source at SPring-8.

Summary for 5WQC

• Entry DOI: 10.2210/pdb5wqc/pdb
• Descriptor: Orexin receptor type 2,GlgA glycogen synthase,Orexin receptor type 2, N-ethyl-2-[(6-methoxypyridin-3-yl)-(2-methylphenyl)sulfonyl-amino]-N-(pyridin-3-ylmethyl)ethanamide, OLEIC ACID, ... (5 entities in total)
• Functional Keywords: g protein-coupled receptor, orexin neurotransmitters, orexin 2 receptor, orexin-a, orexin-b, empa, n-linked glycosylation, signaling protein
• Biological source: Homo sapiens (Human); More
• Cellular location: Cell membrane ; Multi- pass membrane protein : O43614
• Total number of polymer chains: 1
• Total formula weight: 66310.00

Authors

Suno, R.,Hirata, K.,Yamashita, K.,Tsujimoto, H.,Sasanuma, M.,Horita, S.,Yamamoto, M.,Rosenbaum, D.M.,Iwata, S.,Shimamura, T.,Kobayashi, T. (deposition date: 2016-11-25, release date: 2017-11-29, Last modification date: 2018-01-17)

• Primary citation: Suno, R.,Kimura, K.T.,Nakane, T.,Yamashita, K.,Wang, J.,Fujiwara, T.,Yamanaka, Y.,Im, D.,Horita, S.,Tsujimoto, H.,Tawaramoto, M.S.,Hirokawa, T.,Nango, E.,Tono, K.,Kameshima, T.,Hatsui, T.,Joti, Y.,Yabashi, M.,Shimamoto, K.,Yamamoto, M.,Rosenbaum, D.M.,Iwata, S.,Shimamura, T.,Kobayashi, T.; Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA; Structure, 26:7-19.e5, 2018; PubMed: 29225076; DOI: 10.1016/j.str.2017.11.005

Experimental method

X-RAY DIFFRACTION (1.96 Å)