5WIT

Crystal structure of the Thermus thermophilus 70S ribosome in complex with pikromycin and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution

This is a non-PDB format compatible entry.

Summary for 5WIT

• Entry DOI: 10.2210/pdb5wit/pdb
• Descriptor: 23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (62 entities in total)
• Functional Keywords: macrolide, antibiotic, inhibitor, inhibition of translation, peptidyl transferase center, ribosome
• Biological source: Escherichia coli; More
• Total number of polymer chains: 112
• Total formula weight: 4561947.66

Authors

Almutairi, M.M.,Svetlov, M.S.,Hansen, D.A.,Khabibullina, N.F.,Klepacki, D.,Kang, H.Y.,Sherman, D.H.,Vazquez-Laslop, N.,Polikanov, Y.S.,Mankin, A.S. (deposition date: 2017-07-20, release date: 2018-02-14, Last modification date: 2023-11-15)

• Primary citation: Almutairi, M.M.,Svetlov, M.S.,Hansen, D.A.,Khabibullina, N.F.,Klepacki, D.,Kang, H.Y.,Sherman, D.H.,Vazquez-Laslop, N.,Polikanov, Y.S.,Mankin, A.S.; Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins.; Nucleic Acids Res., 45:9573-9582, 2017; PubMed: 28934499; DOI: 10.1093/nar/gkx673

Experimental method

X-RAY DIFFRACTION (2.6 Å)