5WIN

JAK2 Pseudokinase in complex with JNJ7706621

Summary for 5WIN

• Entry DOI: 10.2210/pdb5win/pdb
• Descriptor: Tyrosine-protein kinase JAK2, 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzenesulfonamide (3 entities in total)
• Functional Keywords: jak2, pseudokinase, jnj7706621, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 32075.72

Authors

Li, Q.,Eck, M.J.,Li, K.,Park, E. (deposition date: 2017-07-19, release date: 2018-08-01, Last modification date: 2024-03-13)

• Primary citation: McNally, R.,Li, Q.,Li, K.,Dekker, C.,Vangrevelinghe, E.,Jones, M.,Chene, P.,Machauer, R.,Radimerski, T.,Eck, M.J.; Discovery and Structural Characterization of ATP-Site Ligands for the Wild-Type and V617F Mutant JAK2 Pseudokinase Domain.; ACS Chem. Biol., 14:587-593, 2019; PubMed: 30763067; DOI: 10.1021/acschembio.8b00722

Experimental method

X-RAY DIFFRACTION (2.38 Å)